Promotes: Longevity • Joint Strength • Liver Detoxification • Mood and Brain Function. Jarrow FORMULAS pharmaceutical grade stabilized SAM-e Joint provides a full 200 mg SAM-e (net yield) and 525 mg of glucosamine hydrochloride in every enteric-coated tablet. SAM-e Joint is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAM-e and glucosamine are known to benefit joint function and recuperation.  . Contains More of the Active SS Form.  . SAM-e. Found in all living cells SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and therefore consists of two forms: (SS) SAM-e and (RS) SAM-e. The biologically active form is the (SS) structure while the (RS) structure is biologically inactive. jarrow Formula's SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (SS) SAM-e the highest active level available. Glucosamine. Glucosamine is an aminosaccharide synthesized by transamidase enzymes from glucose and an amine group from glutamine. HCl (hydrochloric acid) stabilizes the glucosamine in this product. Glucosamine is a component of joint and intestinal tissue and is involved in the production of synovial fluid which lubricates the joints. SAM-e has been clinically shown to have the following benefits. Joint Strength. SAM-e supports the production of healthy connective tissue through transulfuration. In this process critical components of connective tissue including glucosamine and the chondroitin sulfates are sulfated by SAM-e metabolites. Brain Metabolism. SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa dopamine and related hormones epinephrine and phosphatidylcholine (a component of lecithin). Longevity. Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity. Liver. SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase) which are substances important for liver function. Full potency 200 mg elemental SAM-e is derived from 400 mg of SAME-e tosylate disulfate.